Botox® is by far the most popular botulinum toxin treatment for cosmetic concerns, but it’s not the only one. Several botulinum toxin type A products have received FDA approval, including Dysport® and Xeomin®.
While these competitors are similar to Botox, they’re not identical formulations and have fewer FDA-approved indications.
One newer alternative that’s gaining popularity for aesthetics is Jeuveau®. Developed by Evolus, Jeuveau is approved for cosmetic injection treatments for frown lines.
When debating between Jeuveau vs. Botox, understanding how these two injectables compare and contrast is essential for creating realistic expectations and finding the treatment that’s right for you.
In this guide, we’ll answer the question of what the difference is between Botox and Jeuveau while also discussing their similarities. We’ll also explain how these medications work, how long they last, their FDA approvals, pricing considerations, and when each may be best utilized to reach your cosmetic goals.
What Is Botox?
Botox is used for both cosmetic and medical indications. Medically, it can be used for treatments such as blepharospasm and chronic migraine.
Botox Cosmetic is the formulation used for cosmetic indications, which include glabellar lines (frown lines), horizontal forehead lines, and crow’s feet. It may be used off-label for other cosmetic applications, including wrinkles or fine lines elsewhere on the face and neck.
What Is Jeuveau and How Does It Work?
Jeuveau® is one of the newer neuromodulators on the U.S. market. Unlike Botox, which is also used for medical indications, Jeuveau was designed specifically for cosmetic applications.
Jeuveau temporarily relaxes targeted facial muscles. Like Botox, it works by blocking communication between nerves and the muscles responsible for dynamic wrinkles. This softens expression lines and creates a smoother, more youthful appearance.
So far, the FDA has approved only one use, for treating moderate to severe frown lines. But like Botox, Jeuveau is also used off-label. And because it’s fairly new to the market, having received FDA approval only in 2019, more approved indications could follow.
So, is Jeuveau better than Botox? The answer largely depends on what you’re seeking in a botulinum toxin treatment. Many injectors find Jeuveau effective for patients seeking a natural look or a more budget-friendly treatment.
Comparing Botox vs. Jeuveau
Some patients may ask: Is Jeuveau the same as Botox? Both are neuromodulator injections derived from botulinum toxin, one of the most powerful known neurotoxins. They have similar molecular weights and safety profiles. However, it’s important to understand the difference between Botox and Jeuveau before making a decision about which is right for you.
Active Ingredient
The active ingredient in Botox is onabotulinumtoxinA. The active ingredient in Jeuveau is prabotulinumtoxinA. Since both work on the nervous system in the same way, there’s no practical difference between the two for the vast majority of patients and providers.
FDA Indications
As noted, Botox has a large number of cosmetic and medical FDA approvals, while Jeuveau’s only current FDA-approved indication is the treatment of frown lines for cosmetic use. FDA approval is one of the key differences when discussing Botox vs. Jeuveau.
Manufacturer
Botox is manufactured under license from AbbVie through its subsidiary Allergan. It is manufactured at a facility located in the Republic of Ireland.
Jeuveau is manufactured by Evolus, a pharmaceutical company based in California. It’s manufactured at a facility in South Korea.
Treatment Applications and Common Use Areas for Botox® and Jeuveau®
Both neuromodulators treat dynamic wrinkles—lines formed by repeated facial movement. However, thanks to Botox’s long history, it is used for both cosmetic and medical applications, while Jeuveau is currently only used cosmetically.
Common treatment areas for Botox include:
• Glabellar lines (frown lines)
• Forehead creases
• Crow’s feet
• Bunny lines on the nose
• Neck banding (platysmal bands)
• Jawline slimming via masseter reduction
• Excessive sweating (hyperhidrosis)
• Medical concerns such as migraines, muscle spasms, or eyelid twitching
Common treatment areas for Jeuveau include:
• Moderate to severe frown lines
• Forehead wrinkles (off-label)
• Crow’s feet (off-label)
• Early-stage wrinkle prevention ("prejuvenation")
• General smoothing of dynamic lines for younger or first-time patients
While both Botox and Jeuveau can be used off-label for comparable treatment areas, many providers will choose based on the patient’s goals, health profile, budget, and how quickly they expect to see results.
Pricing and Patient Considerations: Botox vs. Jeuveau
Providers are free to set their own prices for Botox or Jeuveau treatments. Special offers, package deals, discounts, and other promotions complicate efforts to pin down “typical” neuromodulator pricing or even establish a reasonable range.
That said, Jeuveau generally begins at a lower price point than Botox. This is a function of the manufacturer’s lower marketing and R&D costs. Additionally, the development and approval pathway for agents with both medical and cosmetic indications (like Botox) carries far greater expense than the process for products limited to cosmetics (like Jeuveau).
Results and Duration: How Long Botox and Jeuveau Last
Jeuveau and Botox injections both typically begin showing results within 3 to 5 days, with full effects visible within 1 to 2 weeks.
Side Effects
Both Jeuveau and Botox have undergone rigorous clinical trials to assess their efficacy and risk profiles. The results indicate that both treatments are widely regarded as safe and effective for healthy patients. However, both medications do possess some potential side effects and complications, including:
• Bruising and minor swelling at the injection site
• Minor pain or itchiness at the injection site
• Mild headache or fatigue after injection
These side effects are usually temporary and self-limiting. More serious complications from Jeuveau or Botox, such as drooping eyelids or muscle weakness, are rarer and generally occur only when the medication travels beyond the injection site.
Can You Use Botox® and Jeuveau® Together?
While Botox and Jeuveau are not typically used together in the same treatment area, some experienced practitioners may use them within the same patient appointment, just not on overlapping muscles.
For example, a provider might choose Jeuveau for the glabella but prefer Botox for the crow’s feet based on a patient’s request or their own recommendation.
Using both products in the same visit is safe as long as dosing, placement, and timing are managed by a medical professional. Patients should always receive clear guidance on why different neuromodulators may be recommended for different facial regions.
Choosing Between Botox® and Jeuveau® for Your Aesthetic Practice
For aesthetic practices, the debate between Jeuveau vs. Botox can come down to several different factors. Key considerations include:
• Patient demographic: Younger patients or first-timers often gravitate toward Jeuveau because of its aesthetic-focused branding.
• Treatment philosophy: Providers experienced with Botox may prefer its consistency and long, successful track record.
• Cost and value: Jeuveau may be more attractive for price-sensitive patients due to its lower overall price point.
• Patient goals: Some patients prioritize longevity, while others prefer a softer or quicker onset.
Ultimately, both of these products are safe, effective, and versatile. The most important factor for a provider is matching the right neuromodulator to the patient’s goals and medical history.
Learn How to Administer Botox Injections with Empire Medical Training
Empire Medical Training offers comprehensive, hands-on instruction for medical professionals who want to expand their aesthetic practice with neuromodulator treatments like Botox. Our Botulinum toxin training courses provide in-depth education on facial anatomy, dosing strategies, injection techniques, patient selection, and complication management.
Whether you are new to aesthetic medicine or looking to refine your skills, our nationally recognized training programs are designed to help you safely and confidently incorporate Botox injections and other neuromodulators into your practice.
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