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Certification Curriculum

Certification Program Curriculum

12 modules, 56 lessons and a published formulary of 128 named agents — built so a clinician learns the mechanism, the evidence tier, the patient selection and the regulatory status of everything they prescribe.

12Modules
56Lessons
128Named Agents Studied
2Certification Levels

336 specific topics are published below, lesson by lesson. Delivery spans in-person courses, on-demand video, livestream classes and a 2-day in-person workshop. Scope is stated in modules, lessons, topics and named agents; no hour counts are claimed before the founding cohort is scheduled.

Amber pharmaceutical vial with a silver crimp cap
The Full Picture

The program, in depth

Clinical medicine, compliance & regulatory, and business implementation — a structured pathway from the foundations of peptide science to advanced application. Open any topic for the full picture.

From foundation to advanced clinical application

For clinicians newer to peptide therapy, the program establishes the scientific and clinical foundations this rapidly evolving field demands. For experienced practitioners in functional, integrative, regenerative or longevity medicine, the curriculum progresses into advanced clinical decision-making: patient assessment, laboratory evaluation, case-based application, therapeutic selection and monitoring.

The objective is not simply to teach what a peptide does — it is to teach when, why and how to think about peptide therapy based on the individual patient.

128 formulary agents — patient first, peptide second

The curriculum covers the full 128-agent Peptide Formulary, but never as a menu of products and protocols. Education is organized around patient conditions, clinical presentations, laboratory findings and therapeutic objectives — peptide therapy taught as one part of a larger strategy that keeps nutrition, lifestyle, screening and preventive medicine at the center.

Expert faculty who practice this medicine

Empire’s faculty are highly credentialed physicians and healthcare professionals with years of real-world experience in functional medicine, peptide therapy, regenerative medicine and metabolic health. The curriculum also introduces evolving international developments in peptide medicine — perspective that extends well beyond introductory peptide education.

The compliance advantage

Knowing peptide science is only part of practicing responsibly. A distinctive feature of the program is dedicated healthcare-law education taught in collaboration with an experienced healthcare law firm — regulatory compliance, documentation, medical necessity, prescribing, compounding, practice structure and delegation.

The objective is not to turn clinicians into attorneys. It is to help you recognize the regulatory issues that matter, ask the right questions, and build a compliance-conscious peptide practice.

Compounding & pharmacy considerations

Dedicated education addresses pharmaceutical compounding and its role in peptide therapy — clinical, quality, sourcing and regulatory considerations relevant to every prescriber, and of particular value to pharmacists and compounding professionals.

Pharmacists: explore the dedicated pharmacy & compounding page →

The business of peptide therapy

Clinical knowledge is only valuable if you know how to implement it. Module 11 takes the education beyond the classroom: program development, pricing and fee structures, practice operations, patient management and retention — the practical playbook for a financially sustainable functional and peptide medicine practice.

Learn the medicine. Understand compliance. Build the business.

A certification you actually earn

The credential is not awarded for watching videos or attending a course. Candidates progress through the curriculum, pass a quiz after every lesson, sit a comprehensive written examination, and submit documented clinical cases reviewed by Empire’s physician faculty. Rigorous but achievable — when you earn an Empire peptide certification, it means something.

Designed for licensed healthcare professionals

The program is developed for physicians, nurses, physician assistants, pharmacists and — where applicable — dentists. The curriculum is relevant across these disciplines while recognizing differences in professional scope, prescribing authority and clinical application.

Comprehensive doesn’t have to mean a year

Through a designed combination of self-paced video curricula, faculty-led livestream education and in-person training, motivated participants maintaining the recommended pace complete the program in approximately three months — without the six-to-twelve-month scheduling of some other certification programs.

Understand the patient. Understand the science. Understand the regulations. Learn the business. Earn the certification. This is peptide therapy training — the Empire way.

The Curriculum

The 10 clinical modules in full

Open any lesson to read its published topic list — every module, lesson and topic in the certification is published right here. Nothing is hidden until you enroll.

In this module
  • Semaglutide
  • Sermorelin
  • CJC-1295
Module 1 · 4 lessons · 28 topics

Foundations & Peptide Science

The pharmacologic bedrock every later module assumes: how peptides signal rather than replace, what determines a protocol's route and cadence, and how to judge whether a peptide's evidence base is a human trial or a rat study. Empire teaches literature appraisal as a graded competency, not an aside.

1.1Peptide Signaling Biology & Receptor Pharmacology
  • Peptides as signaling molecules versus small-molecule drugs and hormone replacement
  • Receptor classes encountered in peptide practice (GPCR, receptor tyrosine kinase, nuclear, ion-channel) and how class predicts the side-effect profile
  • Agonist, partial agonist, antagonist and biased-signaling concepts applied to named agents
  • Endogenous versus synthetic analogs: why sequence modification changes selectivity
  • Downstream second-messenger cascades studied in peptide literature (cAMP, PI3K/Akt, NF-κB, AMPK, mTOR)
  • Receptor desensitization, tachyphylaxis and the rationale behind cycling schedules
  • Species-to-species receptor differences and why they limit preclinical extrapolation
1.2Pharmacokinetics, Routes & Delivery Systems
  • Absorption, distribution, metabolism and elimination of peptide therapeutics
  • Enzymatic degradation, DPP-4 cleavage and half-life engineering (acylation, pegylation, DAC/albumin binding, stapling)
  • Subcutaneous and intramuscular administration: depot behavior, site selection, rotation
  • Intranasal delivery and blood-brain-barrier considerations for neuropeptides
  • Oral and liposomal peptide delivery: bioavailability limits and the formulation claims to interrogate
  • Topical and transdermal peptide delivery, penetration enhancers and microneedling-assisted uptake
  • Dosing cadence: pulsatile versus continuous exposure and what each is studied to model
1.3Reconstitution, Dosing Math, Storage & Stability
  • Lyophilized product handling, diluent selection (bacteriostatic water, sterile water, sodium chloride)
  • Concentration math: mg/mL, units on an insulin syringe, dead-space and draw-up error
  • Multi-agent vial planning and the arithmetic behind blended prescriptions
  • Cold-chain requirements, beyond-use dating and what degrades a peptide in the patient's refrigerator
  • Light, temperature, freeze-thaw and pH stability factors documented on a certificate of analysis
  • Patient-facing reconstitution instruction and teach-back verification
  • Sharps, disposal and home-storage counseling in the medical record
1.4Evidence Literacy: Reading the Peptide Literature
  • Evidence tiers applied to peptides: mechanistic, in vitro, animal, case series, controlled human trial
  • Reading a rodent tendon-healing study and stating precisely what it does and does not support
  • Trial design literacy: endpoints, powering, blinding, surrogate versus clinical outcomes
  • Identifying preprints, predatory journals, sponsor-funded reviews and conference abstracts without full data
  • Grading the evidence behind a claim before it is repeated to a patient
  • Translating an evidence tier into consent language and expectation-setting
  • Building and maintaining a personal evidence file per agent that is refreshed as literature moves

Primary agents taught in this module (as teaching exemplars) — 8 named

  • Semaglutide
  • Sermorelin
  • CJC-1295
  • BPC-157
  • GHK-Cu
  • SS-31
  • PT-141
  • Tesamorelin
In this module
  • BPC-157
  • KPV
  • TB-500 / Thymosin beta-4
Module 2 · 4 lessons · 30 topics

Regulatory, Sourcing & Compounding Quality

Peptide regulation moved twice since 2023 and is still moving. This module makes regulatory fluency part of the credential — including gray-market sourcing risk, advertising law, and interstate telehealth prescribing.

2.1The 503A / 503B Framework and the Bulks List
  • Sections 503A and 503B of the FD&C Act: patient-specific compounding versus outsourcing facilities
  • The 503A bulk drug substances list: Category 1, Category 2 and what each designation actually permits
  • The 2023 Category 2 placements and the practices they disrupted
  • April 2026: twelve peptides removed from Category 2 — and why removal is not clearance or approval
  • July 2026 PCAC: recommendations for BPC-157, KPV, TB-500 and MOTS-c are advisory; FDA determination is pending
  • Notice-and-comment rulemaking: how a substance actually reaches the bulks list, and the absence of a fixed timeline
  • Nominations, withdrawals and per-agent status divergence within a single drug class
  • Building a monitoring routine: dockets, PCAC agendas, pharmacy notices and quarterly protocol review
2.2Sterile Manufacturing & the "For Human Use" Difference
  • USP <797> and <800> concepts a prescriber should be able to ask about
  • Cleanroom classification, ISO environments, media fills and personnel qualification
  • API grade and provenance: "for human use" versus research-grade material
  • Sterility, endotoxin (LAL) and bacterial-burden testing
  • Potency, purity and identity assays; HPLC and mass spectrometry basics for reading a report
  • Excipients, preservatives and container-closure integrity
  • Batch records, lot traceability and recall handling
2.3Pharmacy Vetting, Certificates of Analysis & Gray-Market Risk
  • A structured pharmacy due-diligence questionnaire the practice can reuse
  • Reading a certificate of analysis line by line and spotting the missing assay
  • Third-party versus in-house testing and how to request independent verification
  • State board licensure, non-resident pharmacy registration and inspection history
  • "Research use only" and "not for human consumption" supply: the legal, clinical and malpractice exposure
  • Counterfeit and adulterated product patterns reported in the peptide supply chain
  • Documenting sourcing decisions so the chart shows the diligence that was performed
  • Contingency planning when an agent's compounding availability changes mid-protocol
2.4Advertising, Telehealth & Interstate Prescribing Compliance
  • FDA rules on promotion of compounded preparations and unapproved uses
  • FTC substantiation standards for health claims, before-and-after imagery and testimonials
  • Social media, influencer and affiliate arrangements: disclosure and liability
  • State-by-state variation in compounding, office-use and prescribing authority
  • Telehealth prescribing: licensure in the patient's state, establishing the relationship, modality rules
  • Interstate shipping of compounded preparations and the pharmacy's own limits
  • Website, intake-form and consent-language review against the claims the practice actually makes

Primary agents taught in this module — 17 named

  • BPC-157
  • KPV
  • TB-500 / Thymosin beta-4
  • MOTS-c
  • GHK-Cu
  • Semax
  • Epitalon
  • DSIP
  • Melanotan II
  • LL-37
  • PEG-MGF
  • Dihexa
  • GHRP-2
  • GHRP-6
  • Ipamorelin
  • Semaglutide
  • Tirzepatide
In this module
  • Semaglutide
  • Tirzepatide
  • Retatrutide
Module 3 · 5 lessons · 37 topics

Metabolic Health & Weight Management

The incretin class in full — approved branded products, compounded supply, and the investigational triple agonists — plus the operational reality of running a weight-management program. Empire teaches the entire patient arc: selection, titration, muscle preservation, discontinuation and maintenance.

3.1Incretin Physiology, Glucose & Insulin Regulation
  • GLP-1, GIP and glucagon receptor biology and the enteroinsular axis
  • Glucose-dependent insulin secretion, glucagon suppression and gastric emptying
  • Central appetite and reward signaling studied in the incretin literature
  • Insulin resistance, hyperinsulinemia and the metabolic phenotype in front of you
  • Interpretation of fasting insulin, HOMA-IR, HbA1c, continuous glucose data and lipid subfractions
  • Peptide-adjacent metabolic agents studied alongside incretins (MOTS-c, metformin, 5-Amino-1MQ)
  • Metaflammation: the inflammatory-metabolic overlap that connects this module to Module 6
3.2The GLP-1 / GIP / Glucagon Agent Class in Full
  • Semaglutide: formulations, route options and the STEP and SELECT trial programs
  • Tirzepatide: dual GIP/GLP-1 agonism and the SURMOUNT and SURPASS programs
  • Liraglutide, dulaglutide, exenatide and lixisenatide — class positioning and dosing structures
  • Retatrutide and the investigational triple-agonist pipeline; survodutide and mazdutide
  • Amylin biology: pramlintide and cagrilintide co-agonist strategies
  • Melanocortin-pathway obesity pharmacology and defined genetic indications (setmelanotide)
  • Compounded versus branded supply: what changed, what the pharmacy can legally supply, and what to document
  • Dose-equivalence errors, unit-versus-milligram confusion and the reported harm patterns
3.3Body Composition, Muscle Preservation & Metabolic Assessment
  • Body-composition measurement: DEXA, BIA, circumference and photographic standards
  • Lean-mass loss during rapid weight reduction and what the trial data actually report
  • Protein targets, resistance-training prescription and the evidence behind each
  • Adjuncts studied for lean-mass preservation and the strength of that evidence (GH-axis agents, bimagrumab, SARMs as context)
  • Resting metabolic rate, adaptive thermogenesis and plateau physiology
  • Sarcopenia screening and the older adult on an incretin
  • Bone density considerations during sustained caloric restriction
3.4Titration, Tolerability & Adverse-Effect Management
  • Structured titration schedules and when to hold, reduce or extend an interval
  • Nausea, vomiting, constipation, diarrhea and reflux: stepwise management algorithms
  • Gastroparesis, ileus and the presentations that require imaging or referral
  • Pancreatitis and gallbladder events: screening, counseling and workup thresholds
  • Thyroid C-cell and MEN2 contraindications; family-history screening at intake
  • Hypoglycemia risk when combined with sulfonylureas or insulin
  • Injection-site reactions, technique correction and site rotation
  • Aesthetic and quality-of-life complaints (facial volume loss, hair shedding) and the honest framing of each
3.5Discontinuation, Maintenance & GLP-1 Program Operations
  • Weight regain data after cessation and how it is presented at consent, not at month nine
  • Tapering strategies, maintenance dosing and intermittent schedules studied in the literature
  • Off-ramp planning: nutrition, training and behavioral support built into the program from day one
  • Visit cadence, refill workflow, prior authorization and cash-pay program structure
  • Staff roles: intake, injection teaching, check-in calls and escalation criteria
  • Outcome tracking that survives audit: weights, labs, adverse events, adherence
  • Supply interruption playbook when a compounded product becomes unavailable

Primary agents taught in this module — 22 named

  • Semaglutide
  • Tirzepatide
  • Retatrutide
  • Liraglutide
  • Dulaglutide
  • Exenatide
  • Lixisenatide
  • Survodutide
  • Mazdutide
  • Cagrilintide
  • Pramlintide
  • Setmelanotide
  • Tesamorelin
  • AOD-9604
  • MOTS-c
  • Adipotide
  • 5-Amino-1MQ
  • Bimagrumab
  • Metformin
  • Anamorelin
  • Suprefort
  • Pancragen
In this module
  • Sermorelin
  • CJC-1295 (with and without DAC)
  • Tesamorelin
Module 4 · 4 lessons · 29 topics

Growth Hormone Axis, Anabolic & Performance

The full secretagogue landscape — GHRH analogs, ghrelin-receptor agents, IGF-1 biology and the myostatin pathway — taught with per-agent regulatory status rather than class generalization. Includes dedicated anti-doping content for clinicians treating athletes.

4.1The GH / IGF-1 Axis and Secretagogue Classes
  • Hypothalamic–pituitary–somatotroph physiology and pulsatile GH release
  • GHRH receptor versus ghrelin receptor (GHS-R1a) signaling and why the two classes are combined
  • IGF-1, IGFBP-3 and the acid-labile subunit: what each lab value represents
  • Somatostatin tone, sleep-stage timing and the rationale for pre-sleep dosing
  • Adult GH deficiency: diagnostic criteria, stimulation testing and the diagnostic role of macimorelin
  • Secretagogue stimulation versus exogenous recombinant GH — clinical, legal and ethical distinction
  • Per-agent regulatory divergence within the class: why GHRP-2/GHRP-6, ipamorelin and tesamorelin are not interchangeable
4.2GHRH Analogs and Ghrelin-Receptor Agents in Practice
  • Sermorelin and the GRF(1-29) sequence; CJC-1295 with and without DAC
  • Tesamorelin: visceral adipose tissue and hepatic steatosis endpoints, its HIV-lipodystrophy approved indication, and the cognitive endpoints under study
  • ALRN-5281 and stapled long-acting GHRH analogs in early clinical study
  • Ipamorelin, GHRP-2, GHRP-6, hexarelin: selectivity, cortisol and prolactin effects
  • Ghrelin, macimorelin and anamorelin: appetite, cachexia and diagnostic applications
  • MK-677 as an orally active non-peptide secretagogue and its distinct risk profile
  • Combination logic (GHRH analog plus ghrelin agonist) and the evidence behind stacking
  • IGF-1 monitoring intervals, target ranges and stopping rules
4.3Anabolic Signaling, Myostatin & SARMs Context
  • IGF-1 and IGF-1 LR3: receptor affinity, binding-protein evasion and hypoglycemia risk
  • MGF and PEG-MGF: the mechano-sensitive IGF-1 splice variant and its evidence tier
  • Myostatin and activin signaling: follistatin-344 and ACE-031 as investigational probes
  • SARMs — the science, the trial history and the controversy, taught as non-peptide context
  • Adverse events reported with SARM use: hepatotoxicity, lipid changes, HPG-axis suppression
  • Contaminated and mislabeled "research" product analyses in the published literature
  • Counseling the patient who arrives already using an unsupervised anabolic protocol
4.4Athletes, Anti-Doping and Performance Ethics
  • WADA Prohibited List structure: S2 peptide hormones and growth factors, S1 anabolic agents, S0 non-approved substances
  • Which agents in this program are prohibited in and out of competition
  • Therapeutic Use Exemptions: eligibility, documentation and realistic likelihood
  • Collegiate, professional-league and military testing programs and how they differ from WADA
  • Testing methodology basics: isoform tests, biomarker panels, biological passport concepts
  • The clinician's documentation duty when treating a tested athlete
  • Declining to prescribe: how that conversation is conducted and recorded

Primary agents taught in this module — 24 named

  • Sermorelin
  • CJC-1295 (with and without DAC)
  • Tesamorelin
  • GHRH
  • ALRN-5281
  • Ipamorelin
  • GHRP-2
  • GHRP-6
  • Hexarelin
  • Ghrelin
  • Macimorelin
  • Anamorelin
  • MK-677
  • IGF-1 (mecasermin)
  • IGF-1 LR3
  • MGF
  • PEG-MGF
  • Follistatin-344
  • ACE-031
  • SARMs
  • AOD-9604
  • Gonadorelin
  • Kisspeptin-10
  • hCG
In this module
  • BPC-157
  • TB-500 / Thymosin beta-4
  • TB4 fragment 1-4 (Ac-SDKP)
Module 5 · 5 lessons · 36 topics

Regenerative, Musculoskeletal & Organ Repair

The repair cascade end to end: the core reparative peptides, the connective-tissue and bone agents, the organ-directed bioregulators, and the procedural modalities they are combined with. Includes the two-day in-person protocol workshop.

5.1The Repair Cascade & Regenerative Signaling
  • Hemostasis, inflammation, proliferation and remodeling — mapping agents to phase
  • Angiogenesis, fibroblast recruitment and extracellular matrix deposition
  • Growth-factor biology: VEGF, PDGF and the TGF-β superfamily
  • Fibrosis versus functional repair and the agents studied on each side of that line
  • Tendon, ligament, cartilage and bone healing timelines and why they differ
  • Nerve regeneration signaling and the peptides studied in that context
  • Why load, rehabilitation and sleep remain the dominant variables in any repair protocol
5.2Core Reparative Peptides: BPC-157, TB-500 / Thymosin Beta-4, KPV
  • BPC-157: sequence origin, angiogenic and cytoprotective signaling, gastrointestinal and musculoskeletal study models
  • Thymosin beta-4 and TB-500: actin sequestering, cell migration, tissue remodeling
  • TB4 fragment 1-4 (Ac-SDKP): the anti-fibrotic and angiogenic fragment studied separately
  • KPV: the α-MSH C-terminal tripeptide and NF-κB and mast-cell pathways
  • Pentadeca arginate and other marketed BPC analogs — what is and is not established about them
  • Route-to-target reasoning: local versus systemic administration
  • Current regulatory position of each agent, including PCAC recommendation status and its limits
  • Evidence tier disclosure and consent language for tier-four agents
5.3Connective Tissue, Bone & Injury Recovery Protocols
  • Structured intake for the musculoskeletal patient: imaging, diagnosis and surgical thresholds
  • Tendinopathy, ligament sprain and post-operative recovery protocol design
  • Osteoanabolic pharmacology: teriparatide and abaloparatide as approved comparators
  • Cartilage and joint-directed protocols and the honest limits of the evidence
  • Loading, eccentric rehabilitation and physical-therapy coordination
  • Objective recovery metrics: range of motion, strength testing, return-to-activity criteria
  • When the correct answer is orthopedic referral rather than a peptide
5.4Organ-Directed and Bioregulator Repair Peptides
  • The Khavinson short-peptide bioregulator concept and its evidence base, including its geographic publication pattern
  • Pulmonary-directed peptides: taxorest, bronchogen, chonluten
  • Gut-barrier and thymic dipeptides: vilon, thymagen
  • Vascular and cardiac peptides: vesugen, ventfort, cardiogen
  • Cartilage, retinal and endocrine tissue complexes: sigumir, visoluten, suprefort
  • RKH and short peptides studied in sepsis and systemic inflammation models
  • Sourcing, quality and regulatory reality of the bioregulator category in the United States
5.5PRP, Exosomes and Combination Regenerative Procedures
  • Platelet-rich plasma: preparation systems, platelet concentration, leukocyte content and activation
  • Exosomes and extracellular vesicles: biology, product variability and the current US regulatory posture
  • PDRN and polynucleotide agents in tissue and skin protocols
  • Combining biologics with peptide protocols: sequencing, intervals and documentation
  • Ultrasound guidance and injection accuracy for joint and tendon targets
  • Procedural sterility, anesthesia and complication management
  • Photographic and functional outcome documentation standards

Primary agents taught in this module — 25 named

  • BPC-157
  • TB-500 / Thymosin beta-4
  • TB4 fragment 1-4 (Ac-SDKP)
  • KPV
  • Pentadeca arginate
  • RGN-259
  • LL-37
  • VEGF
  • PDGF
  • TGF-β
  • RKH
  • Taxorest
  • Bronchogen
  • Chonluten
  • Vilon
  • Vesugen
  • Ventfort
  • Sigumir
  • Teriparatide
  • Abaloparatide
  • PRP
  • Exosomes
  • PDRN
  • PEG-MGF
  • GHK-Cu
In this module
  • Thymosin alpha-1
  • Thymalin
  • Thymagen
Module 6 · 4 lessons · 28 topics

Immune, Gut & Inflammation

Immune modulation, barrier integrity and inflammation resolution as one connected system — including post-viral and autoimmune protocol design, and the non-peptide adjuncts clinicians actually combine with peptides.

6.1Immune Modulation & Immunosenescence
  • Innate and adaptive immune architecture relevant to peptide signaling
  • Thymic involution, immunosenescence and inflammaging
  • Thymosin alpha-1: T-cell and dendritic-cell signaling and its international regulatory footprint
  • Thymalin, thymagen and thymulin: the thymic bioregulator family and their evidence tier
  • Immune assessment: lymphocyte subsets, immunoglobulins, inflammatory markers
  • Vaccination, infection history and immune-status intake questions
  • Contraindication reasoning in autoimmunity, transplantation and active malignancy
6.2Gut Barrier Integrity & Intestinal Permeability
  • Tight-junction biology, zonulin signaling and what permeability testing can and cannot show
  • Larazotide (AT-1001): mechanism and clinical trial history in celiac disease
  • KPV, BPC-157 and vilon in gut-barrier study models
  • Microbiome fundamentals and where peptides sit relative to diet and targeted therapy
  • Structured GI workup before a permeability-framed protocol is started
  • Distinguishing functional GI symptoms from disease requiring gastroenterology referral
  • Lactoferrin, colostrum-derived proteins and other adjunct mucosal agents
6.3Metaflammation & Resolution Pathways
  • Chronic low-grade inflammation as a metabolic, not infectious, phenomenon
  • NF-κB, inflammasome and cytokine signaling targeted in the peptide literature
  • Specialized pro-resolving mediators: resolution as an active process
  • Low-dose naltrexone: mechanism, evidence tier and how it is combined in protocols
  • TUDCA, glutathione and redox-adjacent adjuncts studied in inflammatory protocols
  • Inflammatory biomarker panels and realistic interpretation of hs-CRP, ferritin, fibrinogen
  • Lifestyle inputs — sleep, training load, alcohol, adiposity — as first-line inflammatory levers
6.4Post-Viral, Neuroimmune & Autoimmune Protocol Design
  • Post-viral syndromes: presentation, differential diagnosis and the boundaries of the evidence
  • VIP and ARA-290 in neuroimmune and chronic inflammatory response models
  • CIRS and biotoxin frameworks: how they are presented in the literature and how to evaluate them critically
  • Mast-cell activation presentations and the agents studied in that setting
  • Autoimmune disease: coordination with rheumatology and the risk of immune stimulation
  • Protocol sequencing, wash-out intervals and single-variable change discipline
  • Defining a stop point and a non-responder definition before starting

Primary agents taught in this module — 19 named

  • Thymosin alpha-1
  • Thymalin
  • Thymagen
  • Thymulin
  • Zinc thymulin
  • KPV
  • BPC-157
  • LL-37
  • VIP
  • ARA-290 / cibinetide
  • Larazotide (AT-1001)
  • Vilon
  • Chonluten
  • RKH
  • TB-500 / Thymosin beta-4
  • LDN
  • SPMs
  • TUDCA
  • Lactoferrin
In this module
  • Semax
  • N-acetyl semax amidate
  • Selank
Module 7 · 4 lessons · 29 topics

Neurocognitive, Mood & Sleep

Neuropeptide pharmacology taught with blood-brain-barrier realism, psychiatric safety and sleep physiology — not as a nootropic catalog. Includes brain-inflammation and neurotherapy content, plus dedicated psychiatric screening.

7.1Neuropeptide Pharmacology & CNS Delivery
  • Blood-brain-barrier transport mechanisms and which peptides plausibly cross
  • Intranasal delivery, olfactory and trigeminal routes, and formulation variables
  • Neurotrophin signaling: BDNF, NGF and HGF/c-Met pathways studied in this class
  • Neurotransmitter modulation studied with peptide agents (GABAergic, serotonergic, dopaminergic)
  • Neurogenesis and synaptogenesis claims and the evidence tier that supports them
  • Cognitive assessment tools appropriate to an outpatient practice
  • Where a peptide protocol ends and a neurology or psychiatry referral begins
7.2Cognition, Mood & Anxiolytic Agents
  • Semax and N-acetyl semax amidate: ACTH-fragment analogs and their study models
  • Selank and N-acetyl selank amidate: tuftsin-analog anxiolytic pharmacology
  • Dihexa: angiotensin IV analog and HGF/c-Met potentiation
  • PE-22-28 (spadin analog), P21 and investigational neurogenic peptides
  • Cortexin, cerebrolysin and cortagen: peptide preparations used outside the United States
  • Noopept and dipeptide-derived nootropics sold in the supplement channel
  • Psychiatric screening: bipolar spectrum, suicidality, stimulant and substance history
  • Interaction review with antidepressants, anxiolytics and stimulants
7.3Brain Inflammation, Neuroimmune & Autoimmune Overlap
  • Neuroinflammation, microglial activation and the blood-brain-barrier in disease models
  • Autoimmune encephalitis and paraneoplastic presentations that must not be missed
  • VIP and ARA-290 in neuroimmune signaling
  • Humanin, MKP and mitochondrial-derived peptides in neuroprotection models
  • Rg3 and Rb1 ginsenosides as non-peptide adjuncts in neuroinflammatory protocols
  • Cognitive complaints in metabolic disease and the overlap with Modules 3 and 8
  • Imaging, laboratory and referral thresholds for the cognitively declining patient
7.4Circadian Biology, Sleep Architecture & Neurotherapy Integration
  • Sleep-stage architecture, slow-wave sleep and the measurement tools available in practice
  • DSIP: nonapeptide sleep and stress-axis study models and its 2026 regulatory movement
  • Pinealon, epitalon and pineal-directed peptides in circadian research
  • VIP and suprachiasmatic circadian signaling
  • Oxytocin and affiliative neuropeptide pharmacology, including its compounded intranasal use
  • Sleep-disordered breathing screening before any sleep-framed protocol
  • Integrating neurofeedback, light, temperature and behavioral sleep interventions

Primary agents taught in this module — 21 named

  • Semax
  • N-acetyl semax amidate
  • Selank
  • N-acetyl selank amidate
  • Dihexa
  • PE-22-28
  • P21
  • Cerebrolysin
  • Cortexin
  • Cortagen
  • Noopept
  • DSIP
  • Pinealon
  • Humanin
  • MKP (Met-Lys-Pro)
  • VIP
  • ARA-290 / cibinetide
  • Oxytocin
  • PT-141
  • Rg3 and Rb1 ginsenosides
  • Epitalon
In this module
  • Epitalon / epithalamin
  • Humanin
  • FOXO4-DRI
Module 8 · 5 lessons · 37 topics

Longevity, Mitochondrial & Senolytics

The geroscience module: hallmarks of aging, mitochondrial-derived peptides, senolytics, the bioregulator literature, and the biological-age testing market — each taught with its evidence tier stated out loud.

8.1Hallmarks of Aging, Cellular Senescence & Telomeres
  • The hallmarks-of-aging framework and which hallmarks peptides are studied against
  • Cellular senescence, the senescence-associated secretory phenotype and "zombie cell" biology
  • Telomere biology, telomerase and the limits of telomere-length testing
  • DNA damage response, genomic instability and epigenetic drift
  • Autophagy and proteostasis pathways relevant to longevity protocols
  • Interpreting the commercial biological-age and telomere testing market critically
  • Communicating geroscience honestly: no life-extension claims, no age-reversal language
8.2Mitochondrial-Derived Peptides & Bioenergetics
  • Mitochondrial genetics, the ORF-derived peptide family and retrograde signaling
  • MOTS-c: insulin sensitivity and metabolic signaling study models, and its PCAC status
  • Humanin and the HNG analog in cytoprotection research
  • SS-31 / elamipretide: cardiolipin binding and its clinical trial history
  • Mitophagy and biogenesis adjuncts studied in protocols (urolithin A, NAD+ precursors)
  • Food-derived bioactive peptides: IRW, LRP and LQP in AMPK and PGC-1α models
  • Mitochondrial function testing: what is measurable in practice and what is not
8.3Senolytics and Senescent-Cell Signaling
  • Senolytic versus senomorphic strategies
  • FOXO4-DRI: the p53–FOXO4 interaction peptide and its preclinical evidence base
  • Dasatinib plus quercetin and the intermittent-dosing trial literature
  • Rapamycin and mTOR inhibition as non-peptide geroscience context
  • Risk framing for senolytic protocols: infection, wound healing, immune surveillance
  • Case-based reasoning on when senolytic experimentation is not appropriate
  • Distinguishing published human data from vendor marketing in this category
8.4Peptide Bioregulators & Geroprotective Agents
  • The Khavinson bioregulator program: hypothesis, publication record and methodological critique
  • Epitalon and epithalamin: pineal peptide research and telomerase claims
  • L-carnosine and glycation chemistry
  • Organ-specific bioregulator complexes: livagen, glandokort-class adrenal, pancragen, testagen, prostamax
  • Oral versus injectable bioregulator formats and the supplement-channel supply reality
  • Constructing a bioregulator protocol that is honest about its evidence tier
  • Documenting a patient's informed choice to use a low-evidence agent
8.5Hormone Signaling, Receptor Modulation & Biological-Age Markers
  • Hormone receptor modulation and cross-talk with peptide signaling pathways
  • The hormone–peptide interface: thyroid, adrenal, gonadal and GH axes in one panel
  • Sex-hormone optimization alongside peptide protocols and the coordination required
  • Epigenetic clocks, biological-age panels and inflammatory-age indices
  • Longitudinal marker tracking: intervals, expected variance and regression to the mean
  • Building a defensible longevity-program monitoring schedule
  • Reporting results to patients without implying lifespan effects
  • The forward pipeline: next-generation peptides and small-molecule longevity therapies in development, and how to appraise a candidate before it reaches your practice
  • Critical appraisal of consumer longevity and biohacking claims: what patients arrive asking for, where the underlying evidence actually sits, and how to redirect the conversation

Primary agents taught in this module — 31 named

  • Epitalon / epithalamin
  • Humanin
  • FOXO4-DRI
  • SS-31 / elamipretide
  • L-carnosine
  • MOTS-c
  • Glutathione
  • NR and NAD+ precursors
  • IRW
  • LRP
  • LQP
  • TUDCA
  • Urolithin A
  • Rapamycin
  • Metformin
  • Dasatinib plus quercetin
  • Vesugen
  • Livagen
  • Cardiogen
  • Ventfort
  • Visoluten
  • Sigumir
  • Suprefort
  • Ovagen
  • Pancragen
  • Glandokort
  • Testagen
  • Prostamax
  • Thymalin
  • Pinealon
  • 5-Amino-1MQ
In this module
  • GHK-Cu
  • Matrixyl (palmitoyl pentapeptide-4)
  • Matrixyl 3000
Module 9 · 5 lessons · 36 topics

Aesthetics, Skin, Hair & Sexual Health

Cosmeceutical peptide chemistry, injectable and procedural skin restoration, hair-restoration protocol design, and the sexual-health and reproductive interface — the aesthetic content taught by a company whose core business is hands-on aesthetic training.

9.1Skin Biology & Cosmeceutical Peptide Chemistry
  • Dermal architecture, collagen types, elastin and the ground substance
  • Matrix metalloproteinase and TIMP balance in photoaging
  • Signal peptides, carrier peptides, neurotransmitter-inhibiting peptides and enzyme-inhibiting peptides
  • GHK-Cu: copper coordination chemistry, gene-expression studies and its three supply pathways
  • Matrixyl, Matrixyl 3000 and palmitoyl tripeptide-38 in topical formulation
  • SNAP-8, Argireline and Syn-Ake: topical neuromodulatory peptide chemistry
  • Reading a cosmeceutical ingredient deck and identifying concentration and vehicle problems
  • Cosmetic-versus-drug regulatory classification and the claims that cross the line
9.2Topical Delivery, Microneedling & Post-Procedure Protocols
  • Stratum corneum penetration, molecular weight limits and delivery vehicles
  • Microneedling depth, device selection and channel-closure timing
  • Peptide application windows relative to laser, peel, radiofrequency and microneedling
  • Infection, granuloma and pigment risk when non-sterile product enters open channels
  • Which products are appropriate for immediate post-procedure application and which are not
  • Building a post-procedure home-care protocol with defined product standards
  • Photographic standardization: lighting, positioning and consent for imagery
9.3Injectable and Combination Skin Restoration
  • Growth-factor and biologic approaches to skin restoration
  • PRP for facial rejuvenation: preparation, layering and combination with microneedling
  • Exosome products in aesthetics and the current US regulatory posture
  • PDRN and polynucleotide skin protocols
  • Combination sequencing with neuromodulators, fillers and energy devices
  • Complication recognition and management in combination aesthetic protocols
  • Outcome measurement and realistic expectation setting for skin-quality interventions
9.4Hair Restoration Protocol Design
  • Alopecia phenotyping: androgenetic, telogen effluvium, cicatricial, autoimmune and nutritional
  • Trichoscopy, pull testing, laboratory workup and standardized outcome photography
  • Regenerative modality selection: PRP, exosomes, PDRN and peptide adjuncts
  • GHK-Cu, zinc thymulin and thymic peptides in hair-follicle research
  • Non-peptide standards of care taught as the comparator: minoxidil and 5-alpha-reductase inhibitors
  • Protocols for female pattern hair loss where hormonal therapy is not appropriate
  • Treatment intervals, maintenance schedules and defining non-response
9.5Sexual Health and the Reproductive–Peptide Interface
  • Melanocortin pathway pharmacology: PT-141 / bremelanotide and its approved indication
  • Melanotan I / afamelanotide and melanotan II: pigmentation pharmacology and reported risk patterns
  • Oxytocin in affiliative and sexual-function research, including its compounded intranasal use
  • Gonadorelin, kisspeptin-10 and hCG in gonadal-axis signaling
  • Male and female sexual-health workup before any peptide is considered
  • Cardiovascular, psychiatric and relational screening in sexual-health consultations
  • Coordination with hormone therapy and the documentation that keeps it defensible

Primary agents taught in this module — 27 named

  • GHK-Cu
  • Matrixyl (palmitoyl pentapeptide-4)
  • Matrixyl 3000
  • Palmitoyl tripeptide-38
  • SNAP-8
  • Argireline
  • Syn-Ake
  • PRP
  • Exosomes
  • PDRN
  • VEGF
  • PDGF
  • TGF-β
  • Zinc thymulin
  • Thymulin
  • Minoxidil
  • Finasteride
  • PT-141 / bremelanotide
  • Afamelanotide
  • Melanotan II
  • Oxytocin
  • Gonadorelin
  • Kisspeptin-10
  • hCG
  • Enclomiphene
  • Testagen
  • Prostamax
In this module
  • Semaglutide
  • Tirzepatide
  • Tesamorelin
Module 10 · 6 lessons · 46 topics

Clinical Practice, Safety & Integration

The module that converts knowledge into a defensible practice: selection, monitoring, adverse events, deprescribing, special populations, consent, scope of practice, medicolegal risk and program economics.

10.1Patient Selection, Screening & Lifestyle Integration
  • Structured intake: goals, history, medications, supplements, prior peptide exposure
  • Red-flag screening that must precede any prescription
  • Baseline risk stratification by comorbidity, age and treatment goal
  • Nutrition assessment and protein, micronutrient and energy-availability targets
  • Exercise prescription integrated with the protocol rather than appended to it
  • Sleep, alcohol, stress and circadian inputs as first-line interventions
  • Global and cultural lifestyle considerations in an international patient population
  • Setting a written goal and a review date before the first dose
10.2Baseline Labs, Monitoring & Longitudinal Response Assessment
  • Core baseline panel: metabolic, lipid, hepatic, renal, thyroid, inflammatory and hematologic
  • Agent-specific baselines: IGF-1, HbA1c, fasting insulin, hormone panels, ceruloplasmin where indicated
  • Monitoring intervals per agent class and the rationale for each
  • Interpreting IGF-1 drift, glycemic change and inflammatory-marker movement on therapy
  • Body composition, functional and imaging endpoints matched to the stated goal
  • When a lab result requires dose reduction, hold or discontinuation
  • Structuring the follow-up visit so the chart demonstrates ongoing evaluation
10.3Adverse Events, Drug Interactions & Deprescribing
  • Adverse-event recognition, grading and documentation workflow
  • Injection-site reactions, infection, abscess and sterile-technique failures
  • Systemic reactions, hypersensitivity and anaphylaxis preparedness in an office setting
  • Class-specific adverse events: incretin GI events, secretagogue glycemic and edema effects, melanocortin pressor and pigmentary effects
  • Drug and supplement interaction review, including anticoagulants, immunosuppressants, insulin and stimulants
  • Absolute and relative contraindications by agent class
  • When not to prescribe: the structured decision framework and how the refusal is documented
  • Deprescribing and stopping rules: non-response, adverse event, goal achieved, evidence changed
10.4Special Populations & Risk Stratification
  • Personal or family history of malignancy: growth-signaling agents and the conservative default
  • Active surveillance, survivorship and coordination with oncology
  • Pregnancy, lactation and patients planning conception
  • Adolescents and patients under 18: consent, growth-plate and ethical considerations
  • Older adults: polypharmacy, frailty, sarcopenia and renal function
  • Athletes subject to drug testing (cross-referenced to Module 4)
  • Renal impairment, hepatic impairment, transplant recipients and immunosuppressed patients
10.5Documentation, Consent, Scope of Practice & Medicolegal Risk
  • Tiered informed consent matched to the agent's evidence and regulatory tier
  • Documenting off-label and compounded-preparation discussions in the patient's own words
  • Chart architecture that would survive a board complaint or malpractice review
  • Scope of practice by license type: physician, NP, PA, RN, dentist, pharmacist — and state variation
  • Supervision, delegation and collaborative-practice agreements for injectable services
  • Malpractice coverage questions to ask a carrier before offering peptide services
  • Board complaints, adverse-event reporting and incident response
  • Record retention, imaging consent and privacy obligations
10.6Practice Economics, Program Design & Case-Based Clinical Reasoning
  • Designing a program rather than selling a vial: visit structure, duration and deliverables
  • Cash-pay operations, transparent pricing structures and refund policy
  • Cost of goods, pharmacy relationships and inventory versus patient-specific dispensing
  • Staff training, role definition, injection teaching and escalation criteria
  • Marketing that satisfies the compliance standards taught in Module 2
  • Measuring program performance: retention, outcomes, adverse events, referral sources
  • Case-based clinical reasoning: multi-domain patients, competing goals and protocol sequencing
  • Faculty-led case panels with graded written reasoning

Primary agents taught in this module (in case-based and safety context) — 16 named

  • Semaglutide
  • Tirzepatide
  • Tesamorelin
  • Sermorelin
  • CJC-1295
  • Ipamorelin
  • BPC-157
  • TB-500
  • KPV
  • GHK-Cu
  • PT-141
  • SS-31
  • MOTS-c
  • Thymosin alpha-1
  • LDN
  • Macimorelin

Regulatory status is summarized as of publication and changes frequently. Agents are named because they are studied in the curriculum — naming an agent is not a recommendation, and no compounded peptide is an FDA-approved product.

Modules 11 & 12

Modules 11 & 12 — Business & Marketing, and Healthcare Law

An MPPC-only benefit: ten lessons on building the practice and keeping it legally defensible — the cash-practice economics Empire has taught for 28 years, and a legal curriculum taught with a healthcare law firm. No other peptide certification includes either.

In this module
  • Clinic economics
  • Marketing & ads
  • Memberships
Module 11 · 5 lessons · 25 topics · MPPC only

The Business of Peptide Therapy

Clinical training tells you how to prescribe; this tells you how to build a practice around it that is profitable, recurring and scalable. Empire has taught cash-practice economics for 28 years — this is that curriculum applied to peptides.

11.1Clinic Economics & Revenue Mix

What a peptide service line actually earns — and how to know before you invest a dollar.

  • Real margin math: cost of goods with a 503A partner, chair time and provider time per protocol
  • Earnings benchmarks by category — weight management, recovery, longevity and aesthetics
  • Pricing a protocol so it is profitable at the first visit, not the tenth
  • Adding peptides alongside your aesthetic, weight-loss or functional lines without cannibalizing them
  • The break-even model: the volume your practice needs before peptides carry their own weight
11.2Package & Membership Design

Turn a recurring therapy into recurring revenue — with pricing patients actually stay in.

  • Why per-vial pricing wastes the recurring nature of peptide therapy
  • Designing 3-, 6- and 12-month programs that match titration and maintenance
  • Membership tiers that produce predictable monthly revenue
  • Bundling labs, follow-ups and touchpoints so packages feel like care, not invoices
  • Renewal and upgrade paths that grow patient lifetime value
11.3Supply Chain & Pharmacy Partnership

Choose a pharmacy partner you can defend — clinically, financially and legally.

  • Vetting a 503A or 503B partner: the questions to ask before you commit
  • Third-party testing and cGMP verification — what the paperwork must show
  • Ordering and inventory workflow that keeps product in date and in stock
  • Contract terms that protect your practice
  • Sourcing decisions that hold up when a board or payer examines them
11.4Growth: Funnels, Retention & Scale

A patient pipeline you control — from first consult to second location.

  • Consult funnels that convert interest into a booked protocol
  • The follow-up cadence that keeps patients adherent — and enrolled
  • Reactivating lapsed patients without discounting your way there
  • What changes structurally with a second provider or a second location
  • The metrics that tell you when to scale — and when not to
11.5Marketing & Advertising a Peptide Practice

Fill your schedule without triggering platform bans or claims problems.

  • Google and Meta ad policies for prescription therapies — what gets accounts banned
  • What you can and cannot say publicly about non-FDA-approved compounds
  • Content and SEO strategy that earns patients instead of renting them
  • Testimonial and before-and-after rules
  • Physician-referral relationships that outlast any ad account

Modules 11 and 12, included in the Master Peptide Practitioner (MPPC) certification program. The clinical curriculum teaches the medicine; these teach the business and the law that carry it.

Side by Side

Compare the peptide certification courses

Every row is a real difference. If you want peptides as a core service line of your practice, the MPPC is the credential to hold.

Comparison of the Peptide Therapy Master Course, the PPC and MPPC certification programs
Compare Single CoursePeptide Therapy Master Course Certification ProgramPeptide Practitioner (PPC) Certification ProgramMaster Peptide Practitioner (MPPC)
What you earn 1 Certificate of Achievement a course certificate, not a certification 2 Certificates of Achievement, one per course, plus the PPC certification
Certification term a course certificate, no term Lifetime $249/yr Annual Recertification adds new videos and tests each year
Price $1,799 monthly payments with Affirm $2,999 was $3,999 · monthly payments with Affirm
Hours of instruction 7+15+
AMA PRA Category 1 Credits 7.57.5
Who teaches it 1 faculty member 2 faculty members one lead faculty member per course
Total lessons 9 all self-paced 18 across the two courses, self-paced
Peptide Therapy Master Course IncludedIncluded
Peptides in Clinical Practice Included
The Business of Peptide Therapy Module 11 — 5 lessons
Healthcare Law for Peptide Practice Module 12 — 5 lessons, taught with a law firm
Full curriculum 12 modules — 10 clinical plus business & marketing and healthcare law — holding 56 lessons, taught livestream
Live workshops 1 live workshop the Peptide Therapy Master Course 2 live workshops the Peptide Therapy Master Course + Peptides in Clinical Practice
In person or livestream Your choice — same price Your choice — same price
Quiz after every lesson YesYes
50-question final exam
Documented patient cases
Typical time to complete self-paced — an estimate, not a deadline One day About a month
Availability Available now Available now
Enroll Enroll Enroll
How the Curriculum Is Delivered

Three formats, matched to the program

A full clinical schedule should not be the barrier to certification. the PPC starts self-paced on demand and finishes with two in-person workshops, and the MPPC is taught livestream and adds two days in person.

Self-Paced, Then In Person

How the PPC runs. All 18 lessons unlock on demand at enrollment — work at your own pace, then attend the Peptide Therapy Master Course and Peptides in Clinical Practice in person to complete the certification.

Livestream Classes

How the MPPC runs. Every module is taught live online by faculty on a set schedule — bring your own patient scenarios and work them through with practicing clinicians.

In-Person Course

What the MPPC adds on top of the livestream classes. One 2-day workshop taught in person by Empire faculty. You build stacks and protocols from a printed guide you keep, and work live cases with the physicians who wrote the curriculum. the MPPC only.

The Assessment

The credential is earned, not attended

the MPPC closes with assessment: 5 documented, de-identified cases with follow-up reviewed by faculty, and a written case-based exam. Case work is assessed on clinical reasoning — patient selection, evidence tier, monitoring plan, regulatory status and the documentation that supports each decision.

The case series is 5 documented, de-identified cases with follow-up. Final counts and exam specifications are confirmed with founding-cohort enrollment.

  • Graded case-study submissions reviewed by faculty
  • Proctored written examination
  • In-person workshop attendance
  • Faculty-led case panels with written clinical reasoning
  • No Empire membership required to certify in either program
Woven Through Every Module

Regulatory fluency is part of the credential

Most therapeutic peptides reach patients through compounding under FDA’s 503A framework, and that landscape moves. In April 2026, FDA removed twelve peptides — including BPC-157, injectable GHK-Cu, and TB-500 — from Category 2 of its compounding categories list. In July 2026, the Pharmacy Compounding Advisory Committee voted to recommend BPC-157, KPV, TB-500, and MOTS-c for the 503A bulks list. That recommendation is advisory: FDA determinations are still pending, and nothing is final.

The curriculum treats that volatility as a clinical skill rather than a footnote. Certified practitioners are trained to tell an FDA-approved peptide drug — semaglutide and tirzepatide as branded products, for example — from a compounded preparation, to read PCAC activity accurately, and to apply their own state’s rules. Compounded peptides are not FDA-approved products, and this program teaches clinicians to communicate that distinction precisely.

  • Lesson 2.1 — the 503A/503B framework, the bulks list, Category 2 and how PCAC actually works
  • Lesson 2.2 — sterile manufacturing and the “for human use” difference
  • Lesson 2.3 — pharmacy vetting, reading a certificate of analysis, gray-market and “research use only” risk
  • Lesson 2.4 — FDA and FTC advertising rules, telehealth and interstate prescribing
  • Lesson 10.5 — tiered informed consent, documentation and scope of practice by license type
  • Ongoing — a monitoring routine for dockets, PCAC agendas, pharmacy notices and quarterly protocol review

Every agent in the Peptide Formulary carries a regulatory status tag. Status is summarized as of publication and will be reviewed as FDA determinations are issued.

Pre-Enrollment Open — MPPC Launches December 1

Enroll in the
Founding Cohort.

The PPC is available now. MPPC pre-enrollment is open at the $4,995 first-cohort rate ahead of the December 1 launch. Call and we will match you to the right program.